TOMM40 and APOE common genetic variants are not Parkinson's disease risk factors

Neurobiol Aging. 2013 Aug;34(8):2078.e1-2. doi: 10.1016/j.neurobiolaging.2013.02.018. Epub 2013 Mar 21.

Abstract

Polymorphic, deoxythymidine-tract in intron 6 of the TOMM40 gene has been associated with Alzheimer's disease. We have investigated the impact of this polymorphism on Parkinson's disease risk and age of onset, independently and in combination with apolipoprotein E alleles, in a group of 407 PD patients and 305 control subjects. No significant association was observed at the single allele, genotype, or haplotype levels. Our data suggest that the polymorphism is not a risk factor for Parkinson's disease in the Polish population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Alleles
  • Apolipoproteins E / genetics*
  • Case-Control Studies
  • Genotype
  • Haplotypes
  • Humans
  • Introns / genetics
  • Membrane Transport Proteins / genetics*
  • Middle Aged
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Parkinson Disease / epidemiology
  • Parkinson Disease / genetics*
  • Poland / epidemiology
  • Polymorphism, Genetic*
  • Risk Factors

Substances

  • Apolipoproteins E
  • Membrane Transport Proteins
  • Mitochondrial Precursor Protein Import Complex Proteins
  • TOMM40 protein, human