The hierarchical brain network for face recognition

PLoS One. 2013;8(3):e59886. doi: 10.1371/journal.pone.0059886. Epub 2013 Mar 20.

Abstract

Numerous functional magnetic resonance imaging (fMRI) studies have identified multiple cortical regions that are involved in face processing in the human brain. However, few studies have characterized the face-processing network as a functioning whole. In this study, we used fMRI to identify face-selective regions in the entire brain and then explore the hierarchical structure of the face-processing network by analyzing functional connectivity among these regions. We identified twenty-five regions mainly in the occipital, temporal and frontal cortex that showed a reliable response selective to faces (versus objects) across participants and across scan sessions. Furthermore, these regions were clustered into three relatively independent sub-networks in a face-recognition task on the basis of the strength of functional connectivity among them. The functionality of the sub-networks likely corresponds to the recognition of individual identity, retrieval of semantic knowledge and representation of emotional information. Interestingly, when the task was switched to object recognition from face recognition, the functional connectivity between the inferior occipital gyrus and the rest of the face-selective regions were significantly reduced, suggesting that this region may serve as an entry node in the face-processing network. In sum, our study provides empirical evidence for cognitive and neural models of face recognition and helps elucidate the neural mechanisms underlying face recognition at the network level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / physiology*
  • Brain Mapping
  • China
  • Cluster Analysis
  • Face*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Models, Neurological*
  • Nerve Net / physiology*
  • Recognition, Psychology / physiology*
  • Students

Grants and funding

This study was funded by the National Natural Science Foundation of China (91132703, 31230031, 30800295 and 31000507) and the National Basic Research Program of China (2010CB833903). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.