Abstract
Tert-butyl hydroperoxide induces in freshly isolated rat hepatocytes malonaldehyde formation and lacticodehydrogenase and aspartate amino-transferase leakage. This model, when adapted to crude extracts, permits the demonstration of both anti-lipoperoxidant and antihepatotoxic activity of reference products like quercetin and silymarin and plant extracts like Rosmarinus officinalis and Eschscholzia californica.
MeSH terms
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Animals
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Aspartate Aminotransferases / metabolism
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L-Lactate Dehydrogenase / metabolism
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Liver / cytology
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Liver / drug effects*
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Liver / metabolism
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Magnoliopsida / analysis
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Male
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Malondialdehyde / metabolism
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Peroxides / toxicity*
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Plant Extracts / pharmacology
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Promethazine / pharmacology
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Quercetin / pharmacology
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Rats
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Silymarin / pharmacology
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tert-Butylhydroperoxide
Substances
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Peroxides
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Plant Extracts
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Silymarin
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Malondialdehyde
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tert-Butylhydroperoxide
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Quercetin
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L-Lactate Dehydrogenase
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Aspartate Aminotransferases
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Promethazine