Abstract
Although all Streptomyces strains are now thought to have 20-30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chemical Fractionation / methods
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Culture Media / chemistry
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Disk Diffusion Antimicrobial Tests
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Escherichia coli / drug effects
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HL-60 Cells
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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MCF-7 Cells
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Molecular Conformation
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Multigene Family
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology
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Pseudomonas aeruginosa / drug effects
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Staphylococcus aureus / drug effects
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Streptomyces / chemistry*
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Streptomyces / genetics
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Streptomyces / isolation & purification
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U937 Cells
Substances
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Antineoplastic Agents, Phytogenic
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Culture Media
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Polyketides
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linearolide A