Abstract
Some biological properties of Bombyx mori sericins from twenty strains were investigated, fourteen fed with artificial diet, two with fresh mulberry leaves and four with both diets. Sericin exhibited ROS-scavenging, anti-tyrosinase and anti-elastase properties, the strain significantly influenced these properties, while diet only influenced the anti-tyrosinase activity. Sericins were clustered into 5 groups and one sericin from each group was further studied: sericins showed anti-proliferative activity on in vitro stimulated peripheral blood mononuclear cells; some strains decreased in vitro secretion of IFNγ, while no effects were observed on TNFα and IL10 release. Therefore, a mixture of sericins extracted from the most promising strains may be useful for dermatological and cosmetic use.
Copyright © 2013 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bombyx / metabolism
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Cell Proliferation / drug effects
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Cytokines / metabolism
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Diet
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Free Radical Scavengers / chemistry*
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Free Radical Scavengers / pharmacology
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Fungal Proteins / antagonists & inhibitors
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Fungal Proteins / chemistry
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Humans
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Immunologic Factors / biosynthesis
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Immunologic Factors / chemistry*
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Immunologic Factors / pharmacology
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / physiology
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Monophenol Monooxygenase / antagonists & inhibitors
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Monophenol Monooxygenase / chemistry
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Pancreatic Elastase / antagonists & inhibitors*
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Pancreatic Elastase / chemistry
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Particle Size
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Powders / chemistry
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Reactive Oxygen Species / chemistry*
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Sericins / biosynthesis
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Sericins / chemistry*
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Sericins / pharmacology
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Species Specificity
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Spectroscopy, Fourier Transform Infrared
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Sus scrofa
Substances
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Cytokines
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Free Radical Scavengers
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Fungal Proteins
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Immunologic Factors
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Powders
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Reactive Oxygen Species
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Sericins
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Monophenol Monooxygenase
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Pancreatic Elastase