Abstract
Combination therapy using medications with complementary mechanisms of action is the standard of care in treating acne. We report results of a clinical trial evaluating the use of a fixed-dose tretinoin 0.025%/clindamycin phosphate 1.2% (T/CP) gel in combination with a benzoyl peroxide 6% foaming cloth compared with T/CP alone for facial acne. At week 12, the combination therapy group showed a trend toward greater efficacy compared with T/CP alone. There was a high success rate observed in the study, which may be attributable to the large percentage of adult female acne patients enrolled. Cutaneous adverse events were not statistically different in using combination therapy compared with T/CP alone.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Acne Vulgaris / drug therapy*
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Acne Vulgaris / pathology
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Administration, Cutaneous
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Adolescent
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Adult
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Benzoyl Peroxide / administration & dosage
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Benzoyl Peroxide / adverse effects
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Benzoyl Peroxide / therapeutic use*
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Clindamycin / administration & dosage
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Clindamycin / adverse effects
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Clindamycin / therapeutic use*
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Dermatologic Agents / administration & dosage
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Dermatologic Agents / adverse effects
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Dermatologic Agents / therapeutic use*
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Drug Combinations
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Drug Therapy, Combination
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Face
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Female
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Gels
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Humans
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Male
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Middle Aged
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Single-Blind Method
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Tretinoin / administration & dosage
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Tretinoin / adverse effects
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Tretinoin / therapeutic use*
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Young Adult
Substances
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Dermatologic Agents
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Drug Combinations
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Gels
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clindamycin, tretinoin drug combination
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Clindamycin
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Tretinoin
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Benzoyl Peroxide