MicroRNA function in NK-cell biology

Immunol Rev. 2013 May;253(1):40-52. doi: 10.1111/imr.12045.

Abstract

The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Cytotoxicity, Immunologic / genetics
  • Homeostasis
  • Humans
  • Immune System Diseases / genetics
  • Immune System Diseases / immunology*
  • Immunomodulation
  • Killer Cells, Natural / immunology*
  • MicroRNAs / genetics
  • MicroRNAs / immunology*
  • Neoplasms / genetics
  • Neoplasms / immunology*
  • RNA Interference / immunology

Substances

  • MicroRNAs