Immune-mediated cytopenias in human immunodeficiency virus: the first reported case of idiopathic aplastic anaemia successfully treated with immunosuppression

Intern Med J. 2013 Apr;43(4):452-5. doi: 10.1111/imj.12087.

Abstract

Although isolated cytopenias are relatively common in human immunodeficiency virus (HIV), the incidence of aplastic anaemia is extremely rare. We report here the first case of a HIV-infected patient who developed severe idiopathic aplastic anaemia, and who was safely and effectively treated with anti-thymocyte globulin and cyclosporin. We briefly review immune-mediated cytopenias in HIV, including their frequency, pathophysiology and management strategies.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anemia, Aplastic / drug therapy*
  • Anemia, Aplastic / etiology*
  • Anemia, Aplastic / immunology
  • Antilymphocyte Serum / administration & dosage
  • Cyclosporine / administration & dosage
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • Humans
  • Immunity, Cellular* / immunology
  • Immunosuppression Therapy / methods*
  • Immunosuppressive Agents / administration & dosage
  • Middle Aged
  • Treatment Outcome

Substances

  • Antilymphocyte Serum
  • Immunosuppressive Agents
  • Cyclosporine