Induced pluripotent stem cell-derived cardiomyocytes: a versatile tool for arrhythmia research

Circ Res. 2013 Mar 15;112(6):961-8. doi: 10.1161/CIRCRESAHA.112.268623.

Abstract

Induced pluripotent stem cells offer the possibility to generate patient-specific stem cell lines from individuals affected by inherited disorders. Cardiomyocytes differentiated from such patient-specific induced pluripotent stem cells lines have been used to study the pathophysiology of arrhythmogenic heart diseases, such as the long-QT syndrome or catecholaminergic polymorphic ventricular tachycardia. Testing for unwanted drug side effects or tailoring medical treatment to the specific needs of individual patients with arrhythmogenic disorders may become future applications of this emerging technology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anti-Arrhythmia Agents / pharmacology
  • Arrhythmias, Cardiac / drug therapy
  • Arrhythmias, Cardiac / pathology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / drug effects
  • Long QT Syndrome / drug therapy
  • Long QT Syndrome / pathology
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / drug effects
  • Phenotype
  • Precision Medicine / methods
  • Tachycardia, Ventricular / drug therapy
  • Tachycardia, Ventricular / pathology

Substances

  • Anti-Arrhythmia Agents