For whom the bell tolls: isoniazid preventive therapy and tuberculosis drug resistance

Sci Transl Med. 2013 Apr 10;5(180):180fs12. doi: 10.1126/scitranslmed.3006094.

Abstract

The expected increase in drug-resistant tuberculosis due to large-scale preventive treatment in people living with HIV calls for reconsidering the "double use" of isoniazid for prophylaxis and curative treatment (Mills et al., this issue).

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Humans
  • Isoniazid / therapeutic use*
  • Tuberculosis / drug therapy*
  • Tuberculosis, Multidrug-Resistant

Substances

  • Antitubercular Agents
  • Isoniazid