Long-term potentiation in intact infant rat hippocampus

Brain Res Dev Brain Res. 1990 May 1;53(2):288-90. doi: 10.1016/0165-3806(90)90020-y.

Abstract

In rats 14-28 days of age, high-frequency stimulation of the perforant path granule cell synapse in the dentate gyrus produced long-term potentiation of the population spike that was comparable in magnitude (150-250% of baseline) and duration (120 min) to that produced in adult animals with the same stimulation paradigm. In contrast, potentiation of the excitatory postsynaptic potential occurred inconsistently.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials
  • Adaptation, Physiological*
  • Aging / physiology*
  • Animals
  • Electric Stimulation
  • Hippocampus / growth & development
  • Hippocampus / physiology*
  • Rats
  • Rats, Inbred Strains