Cell biology: Notch recycling is numbed

Curr Biol. 2013 Apr 8;23(7):R270-2. doi: 10.1016/j.cub.2013.03.013.

Abstract

During asymmetric cell division, the Notch regulator Numb segregates unequally to establish different cell fates in the two daughter cells. Numb is thought to act as an endocytic protein. Two new studies show that Numb antagonizes Notch signaling by also regulating recycling of Sanpodo-Notch complexes via AP-1.

Publication types

  • Comment

MeSH terms

  • Animals
  • Asymmetric Cell Division / physiology*
  • Cell Differentiation / physiology*
  • Drosophila / physiology*
  • Drosophila Proteins / metabolism*
  • Drosophila Proteins / physiology*
  • Endocytosis / physiology*
  • Endosomes / metabolism*
  • Juvenile Hormones / metabolism*
  • Juvenile Hormones / physiology*
  • Microfilament Proteins / metabolism
  • Receptors, Notch / metabolism*

Substances

  • Drosophila Proteins
  • Juvenile Hormones
  • Microfilament Proteins
  • N protein, Drosophila
  • Receptors, Notch
  • numb protein, Drosophila
  • spdo protein, Drosophila