Abstract
Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomycetales / chemistry*
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Dinoprostone / antagonists & inhibitors*
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Dinoprostone / metabolism
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Dose-Response Relationship, Drug
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification*
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Naphthoquinones / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Prostaglandin Antagonists / chemistry
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Prostaglandin Antagonists / isolation & purification*
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Prostaglandin Antagonists / pharmacology*
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Sarcoma, Synovial / drug therapy
Substances
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Naphthoquinones
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Prostaglandin Antagonists
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sacchathridine A
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Dinoprostone