Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control

Jeffrey S Mugridge; John D Gross

doi:10.1016/j.molcel.2013.03.025

Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control

Mol Cell. 2013 Apr 11;50(1):2-4. doi: 10.1016/j.molcel.2013.03.025.

Authors

Jeffrey S Mugridge¹, John D Gross

Affiliation

¹ Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

In this issue of Molecular Cell, Jiao et al. (2013) describe the mammalian enzyme DXO, which has pyrophosphohydrolase, decapping, and 5'-3' exoribonuclease activity and functions as an important checkpoint in cotranscriptional capping of RNA polymerase II (Pol II) pre-mRNA transcripts.

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