Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes

J Clin Pharmacol. 2013 Jun;53(6):670-4. doi: 10.1002/jcph.81. Epub 2013 Apr 15.

Authors

Maria S Ebbesen¹, Jacob Nersting, Jack H Jacobsen, Thomas L Frandsen, Kim Vettenranta, Jonas Abramsson, Finn Wesenberg, Kjeld Schmiegelow

Affiliation

¹ Department of Pediatrics and Adolescent Medicine, The University Hospital Rigshospitalet, Copenhagen, Denmark.

PMID: 23585236
DOI: 10.1002/jcph.81

No abstract available

Publication types

Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Child
DNA / metabolism*
Female
Genotype
Guanine Nucleotides / metabolism
Humans
Male
Mercaptopurine / administration & dosage
Methotrexate / administration & dosage
Methyltransferases / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Thionucleotides / metabolism

Substances

Guanine Nucleotides
Thionucleotides
6-thioguanylic acid
DNA
Mercaptopurine
Methyltransferases
thiopurine methyltransferase
Methotrexate