Negating the dominant-negative allele: a new treatment paradigm for arrhythmias explored in human induced pluripotent stem cell-derived cardiomyocytes

Eur Heart J. 2014 Apr;35(16):1019-21. doi: 10.1093/eurheartj/eht130. Epub 2013 Apr 12.

Authors

Daniel Sinnecker¹, Alessandra Moretti, Karl-Ludwig Laugwitz

Affiliation

¹ Klinikum rechts der Isar-Technische Universität München, First Department of Medicine, Cardiology Division, Ismaninger Strasse 22, D-81675 Munich, Germany.

PMID: 23585490
DOI: 10.1093/eurheartj/eht130

No abstract available

Publication types

Editorial
Comment

MeSH terms

ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels / genetics*
Humans
Long QT Syndrome / genetics*
Myocytes, Cardiac / physiology*
Pluripotent Stem Cells / physiology*
RNA Interference / physiology*

Substances

ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels

Supplementary concepts

Long Qt Syndrome 2