Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis

Cell Res. 2013 May;23(5):728-31. doi: 10.1038/cr.2013.53. Epub 2013 Apr 16.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Antitubercular Agents / chemistry*
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Binding Sites
  • Carbapenems / chemistry*
  • Carbapenems / metabolism
  • Catalytic Domain
  • Crystallography, X-Ray
  • Meropenem
  • Mycobacterium tuberculosis / enzymology*
  • Peptidyl Transferases / chemistry*
  • Peptidyl Transferases / genetics
  • Peptidyl Transferases / metabolism
  • Thienamycins / chemistry*
  • Thienamycins / metabolism

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • Carbapenems
  • Thienamycins
  • Peptidyl Transferases
  • Meropenem

Associated data

  • PDB/3VYN
  • PDB/3VYO
  • PDB/3VYP