Abstract
A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as a receptor only poorly but readily adapted to use it following a P541S substitution in the hemagglutinin protein. Since CYN07-dV had an intrinsic ability to use human nectin-4, the adapted virus became able to use both human immune and epithelial cell receptors, as well as monkey and canine ones, suggesting that CDV can potentially infect humans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological / genetics*
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Amino Acid Substitution
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Animals
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Antigens, CD / metabolism*
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Cell Adhesion Molecules / metabolism*
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Chlorocebus aethiops
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Disease Outbreaks*
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Distemper / epidemiology
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Distemper / virology
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Distemper Virus, Canine / genetics
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Distemper Virus, Canine / metabolism*
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Distemper Virus, Canine / pathogenicity
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Dogs
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Epithelial Cells / metabolism
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Epithelial Cells / virology
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Hemagglutinins, Viral / genetics
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Humans
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Macaca / virology*
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Monkey Diseases / epidemiology
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Monkey Diseases / mortality
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Monkey Diseases / virology*
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Receptors, Cell Surface / metabolism*
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Receptors, Virus / metabolism
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Signaling Lymphocytic Activation Molecule Family Member 1
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Vero Cells
Substances
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Antigens, CD
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Cell Adhesion Molecules
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Hemagglutinins, Viral
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Receptors, Cell Surface
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Receptors, Virus
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NECTIN4 protein, human
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Signaling Lymphocytic Activation Molecule Family Member 1