Introduction: To know the prevalence of primary resistance in chronic hepatitis B naïve patients is essential to decide on the need of routine laboratory testing.
Patients and methods: The genetic sequence of the HBV polymerase from 105naïve patients was analysed.
Results: rtV173L, a lamivudine compensatory mutation, was detected in two patients (1.9%), rtI233V in one patient, and another one carried the sG145R vaccine escape mutation.
Conclusion: Our study shows that studying HBV resistance in naïve patients should not be recommended in the routine laboratory setting, for the time being.
Keywords: Hepatitis B virus; Primary drug resistance; Resistencias primarias; Secuenciación; Sequencing; Virus de la hepatitis B.
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