Abstract
Eighty-nine Staphylococcus aureus strains were grouped according to their susceptibility or resistance to methicillin and oxacillin. The role of beta-lactamase in borderline methicillin resistance was confirmed by tests with beta-lactamase inhibitors, particularly when salt-supplemented medium was used. A penicillin-binding protein assay indicated that borderline methicillin-resistant S. aureus strains do not produce PBP 2a.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins*
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Carrier Proteins / metabolism*
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Hexosyltransferases*
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Methicillin / pharmacology*
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Microbial Sensitivity Tests
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Muramoylpentapeptide Carboxypeptidase / metabolism*
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Oxacillin / pharmacology
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Penicillin G / pharmacology
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Penicillin Resistance*
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Penicillin-Binding Proteins
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Peptidyl Transferases*
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Staphylococcus aureus / drug effects*
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beta-Lactamase Inhibitors
Substances
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Bacterial Proteins
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Carrier Proteins
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Penicillin-Binding Proteins
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beta-Lactamase Inhibitors
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase
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Penicillin G
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Methicillin
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Oxacillin