Clinical diagnostic criteria and classification controversies in frontotemporal lobar degeneration

Int Rev Psychiatry. 2013 Apr;25(2):145-58. doi: 10.3109/09540261.2013.763341.

Abstract

Frontotemporal lobar degeneration (FTLD) can manifest as a spectrum of clinical syndromes, ranging from behavioural impairment to language or motor dysfunction. Recently, revised diagnostic criteria have been proposed for the behavioural and progressive aphasia syndromes associated with frontotemporal degeneration. The present review will summarize these diagnostic guidelines and highlight some lingering controversies in the classification of FTLD clinical syndromes. We will discuss common tools and methods used to identify the insidious changes of behavioural variant frontotemporal dementia (bvFTD), the value of new, patient-based tasks of orbitofrontal function, and the issue of a benign or 'phenocopy' variant of bvFTD. With regard to primary progressive aphasia (PPA), we will discuss the scope of the semantic disorder in semantic-variant PPA, the nature of the speech disorder in non-fluent, agrammatic PPA, and the preliminary utility of a logopenic PPA classification.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aphasia, Primary Progressive / diagnosis
  • Aphasia, Primary Progressive / psychology
  • Decision Making
  • Emotional Intelligence
  • Executive Function
  • Frontotemporal Lobar Degeneration / classification
  • Frontotemporal Lobar Degeneration / diagnosis*
  • Frontotemporal Lobar Degeneration / psychology
  • Humans
  • Neuropsychological Tests
  • Social Adjustment
  • Theory of Mind