The objective of this study was to estimate the extent to which parental psychopathology may confer increased risk of suicide ideation and attempts among their offspring in Mexico. Data from a representative sample of 5,782 respondents participating in the Mexican National Comorbidity Survey (2001-2002) to examine the unique associations between parental psychopathology and offspring suicidality were used. Parental disorders (major depression, panic disorder, generalized anxiety disorder, substance dependence, and antisocial personality disorder) were comorbid and after controlling for comorbidity and number of disorders only parental panic and antisocial personality disorder remained associated with ideation and attempts in the total sample. Those with more parental disorders were at increased risk of ideation and attempt, as well as increased risk to transition from suicide ideation to an attempt. These findings may help inform clinical and public health efforts aimed at suicide prevention in Mexico and other developing countries.