Genetics of ischaemic stroke

J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1302-8. doi: 10.1136/jnnp-2012-304834. Epub 2013 Apr 25.

Abstract

Recent advances in genomics and statistical computation have allowed us to begin addressing the genetic basis of stroke at a molecular level. These advances are at the cusp of making important changes to clinical practice of some monogenic forms of stroke and, in the future, are likely to revolutionise the care provided to these patients. In this review we summarise the state of knowledge in ischaemic stroke genetics particularly in the context of how a practicing clinician can best use this knowledge.

Keywords: CEREBROVASCULAR; CEREBROVASCULAR DISEASE; GENETICS; STROKE.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Ischemia / complications
  • Brain Ischemia / genetics*
  • Demyelinating Diseases / complications
  • Demyelinating Diseases / genetics
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Stroke / complications
  • Stroke / genetics*