The phosphatase PP2A links glutamine to the tumor suppressor p53

Dana Gwinn; E Alejandro Sweet-Cordero

doi:10.1016/j.molcel.2013.04.010

The phosphatase PP2A links glutamine to the tumor suppressor p53

Mol Cell. 2013 Apr 25;50(2):157-8. doi: 10.1016/j.molcel.2013.04.010.

Authors

Dana Gwinn¹, E Alejandro Sweet-Cordero

Affiliation

¹ Cancer Biology Program, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

PMID: 23622513
DOI: 10.1016/j.molcel.2013.04.010

Abstract

In this issue of Molecular Cell, Reid et al. (2013) show that glutamine withdrawal causes PP2A-mediated activation of p53 through its regulator EDD, linking levels of a critical metabolite to an important regulator of cell survival and proliferation.

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