Abstract
Hollow Mn-doped iron oxide nanocontainers, formed by a novel one-pot synthetic process, fulfill the dual requirements of delivering an effective dose of an anticancer drug to tumor tissue and enabling image-contrast monitoring of the nanocontainer fate through T2 -weighted magnetic resonance imaging, thereby determining the optimal balance between diagnostic and therapeutic moieties in an all-in-one theranostic nanoplatform.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / administration & dosage
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Cell Line
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Crystallization
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Doxorubicin / administration & dosage
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Drug Carriers / chemistry
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Ferric Compounds / chemistry*
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Humans
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Hydrogen-Ion Concentration
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Liver Neoplasms / drug therapy
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Manganese / chemistry
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Mice
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Nanostructures / chemistry*
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Particle Size
Substances
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Antibiotics, Antineoplastic
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Drug Carriers
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Ferric Compounds
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ferric oxide
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Manganese
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Doxorubicin