Importance of donor ethnicity/race matching in unrelated adult and cord blood allogeneic hematopoietic cell transplant

Leuk Lymphoma. 2014 Feb;55(2):358-64. doi: 10.3109/10428194.2013.800200. Epub 2013 Jun 12.

Abstract

Donor race matching (both recipient and donor belonging to the same race) might be a factor in outcomes of donor allogeneic hematopoietic cell transplant (alloHCT). A total of 858 patients who underwent umbilical cord blood (UCB) (475 patients: 202 double UCB and 273 single UCB) or unrelated donor (URD) (383 patients) alloHCT between January 1995 and December 2010 were studied. Most patients were Caucasian (87%), followed by Asians (4%), African Americans (3%), Hispanics (3%), mixed race (3%) and American Indians (< 1%). Caucasians constituted 88% of the donor grafts; Caucasians were the most common race of the donor grafts among all races except for Asians. As a result, Caucasians were much more likely to have a race-matched donor than ethnic minorities (91% vs. 33%, p < 0.01). Donor race matching did not affect non-relapse mortality, relapse, acute or chronic graft-versus-host disease or overall survival. Acknowledging the limitations of this study (mainly, self-reported race information and small number of ethnic minorities), at present there are no data supporting that donor race should be considered a factor in donor selection.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Asian People / statistics & numerical data*
  • Black or African American / statistics & numerical data*
  • Cord Blood Stem Cell Transplantation / adverse effects
  • Cord Blood Stem Cell Transplantation / ethnology*
  • Cord Blood Stem Cell Transplantation / methods
  • Female
  • Graft vs Host Disease / ethnology
  • Graft vs Host Disease / etiology
  • Hispanic or Latino / statistics & numerical data*
  • Humans
  • Indians, North American / statistics & numerical data*
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Outcome Assessment, Health Care / statistics & numerical data
  • Survival Analysis
  • Transplantation, Homologous
  • Unrelated Donors / statistics & numerical data*
  • White People / statistics & numerical data*
  • Young Adult