Abstract
The cryptic thioesterase LovG is found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB). The same enzyme also helps improving turnover of LovB through hydrolysis of incorrectly tailored intermediates.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Lovastatin / biosynthesis
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Lovastatin / chemistry*
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Polyketide Synthases / metabolism*
Substances
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lovastatin nonaketide synthase, Aspergillus terreus
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Polyketide Synthases
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Lovastatin