Abstract
Several clinical experiences from Padua, Italy confirm that 5-fluorouracil may be usefully modulated by the addition of leucovorin, and especially by platinum and alpha interferon. The intra-arterial and intraperitoneal administration of such synergistic combinations has also proved to be of benefit in special subsets of patients. Perspectives of further studies are examined.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cisplatin / administration & dosage
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Colonic Neoplasms / drug therapy
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Drug Synergism
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Fluorouracil / administration & dosage
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Fluorouracil / therapeutic use*
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Humans
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Injections, Intraperitoneal
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Injections, Intravenous
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Interferon Type I / administration & dosage
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Leucovorin / administration & dosage
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Methotrexate / administration & dosage
Substances
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Interferon Type I
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Cisplatin
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Leucovorin
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Fluorouracil
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Methotrexate