Abstract
GPER-1 protein expression was immunohistochemically examined in 164 primary breast cancer specimens and their matched normal breast epithelium. GPER-1 down-regulation correlated significantly with increased histological grading (p = .015), lymph node metastases (p = .032), and negative estrogen receptor status (p = .018). The decrease of GPER-1 expression in breast cancer tissue, relative to normal tissue, was associated with poor overall survival (p = .043) and disease-free survival (p = .037) and remained a significant unfavorable factor in multivariate analysis for DFS (HR = 1.569; 95% CI, 1.024-2.797; p = .041) and OS (HR = 2.082; 95% CI, 1.248-4.773; p = .039). Thus aberrant GPER-1 expression seems to be an important factor in breast cancer progression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Breast Neoplasms / metabolism*
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Breast Neoplasms / mortality
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Breast Neoplasms / pathology
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Carcinoma, Ductal, Breast / metabolism*
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Carcinoma, Ductal, Breast / mortality
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Carcinoma, Ductal, Breast / secondary
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Carcinoma, Intraductal, Noninfiltrating / metabolism*
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Carcinoma, Intraductal, Noninfiltrating / mortality
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Carcinoma, Intraductal, Noninfiltrating / secondary
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Cell Transformation, Neoplastic / metabolism*
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Disease-Free Survival
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Female
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Gene Expression
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Humans
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Kaplan-Meier Estimate
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Lymphatic Metastasis
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Middle Aged
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Multivariate Analysis
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Neoplasm Recurrence, Local / metabolism
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Receptors, Estrogen / genetics*
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Receptors, Estrogen / metabolism
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Receptors, G-Protein-Coupled / genetics*
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Receptors, G-Protein-Coupled / metabolism
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Risk Factors
Substances
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GPER1 protein, human
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Receptors, Estrogen
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Receptors, G-Protein-Coupled