Turn-on selective vitamin B6 derivative fluorescent probe for histidine detection in biological samples

Analyst. 2013 Jul 7;138(13):3642-5. doi: 10.1039/c3an00324h.

Abstract

A new compound L soluble in water derived from vitamin B6 was successfully synthesized and characterized. The complex LAl(3+) is a turn-on selective fluorescent probe for histidine in HEPES buffer, with detection and quantification limits of 0.3 μM and 0.6 μM, respectively. The application of the complex LAl(3+) in real urine samples is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Fluorescent Dyes / chemistry*
  • Histidine / urine*
  • Humans
  • Limit of Detection
  • Male
  • Metals / chemistry
  • Spectrometry, Fluorescence
  • Urinalysis / methods*
  • Vitamin B 6 / analogs & derivatives*

Substances

  • Fluorescent Dyes
  • Metals
  • Histidine
  • Vitamin B 6