Light-induced hydrogen sulfide release from "caged" gem-dithiols

Org Lett. 2013 Jun 7;15(11):2786-9. doi: 10.1021/ol401118k. Epub 2013 May 22.

Abstract

"Caged" gem-dithiol derivatives that release H2S upon light stimulation have been developed. This new class of H2S donors was proven, by various spectroscopic methods, to generate H2S in an aqueous/organic medium as well as in cell culture.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes / chemistry*
  • Hydrogen Sulfide / chemistry*
  • Hydrogen Sulfide / pharmacology
  • Hydrolysis
  • Light
  • Molecular Structure
  • Nitric Oxide / chemistry*
  • Nitric Oxide / pharmacology
  • Photolysis
  • Signal Transduction
  • Toluene / analogs & derivatives*
  • Toluene / chemistry
  • Toluene / pharmacology

Substances

  • Fluorescent Dyes
  • Nitric Oxide
  • Toluene
  • dithiol
  • Hydrogen Sulfide