A 14-year experience with aortic endograft infection: management and results

Eur J Vasc Endovasc Surg. 2013 Sep;46(3):306-13. doi: 10.1016/j.ejvs.2013.04.021. Epub 2013 May 20.

Abstract

Objectives: The management of thoracic and abdominal aortic endograft infection is complex and associated with high mortality. Cases are rare: a recent systematic review identified 117 reported cases; the largest reported series comprises 12 infected endografts.

Methods: We report 22 consecutive patients with infected abdominal or thoracic aortic endovascular devices implanted from 1998 to 2012. Management included extension with new devices, aneurysm sac drainage of pus/irrigation with antibiotics, endograft explantation, and axillo-(bi)femoral reconstruction.

Results: Twenty-two patients (16 men) were identified. Median age was 71 years (range, 43-88 years). Index devices were infra-renal endovascular repair (n = 13), and thoracic endovascular repair (n = 9) all for aneurysmal or pseudoaneurysmal disease. Seven (32%) had prior aortic surgery. Follow-up was complete in all cases; in survivors follow-up was a median of 29 (range, 12-45) months. The mortality from explantation of ten infra-renal devices was 1/10 (10%) on-table and a further 2/10 (20%) within 30 days. Device retention led to disease progression and death in all patients with infected endografts. Sac drainage/irrigation provided only temporary control of sepsis. Device extension can treat rupture, but additional devices became infected.

Conclusion: Abdominal endograft explantation is high risk but may be curative. Appropriate selection of patients for infected endograft explantation remains a major challenge.

Keywords: Endograft infection; Explantation; Reconstruction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / therapeutic use
  • Aortic Aneurysm, Abdominal / surgery*
  • Aortic Aneurysm, Thoracic / surgery*
  • Blood Vessel Prosthesis Implantation
  • Blood Vessel Prosthesis*
  • Device Removal
  • Disease Progression
  • Drainage
  • Endovascular Procedures
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Selection
  • Prosthesis-Related Infections / microbiology
  • Prosthesis-Related Infections / mortality
  • Prosthesis-Related Infections / therapy*
  • Retrospective Studies
  • Survival Rate
  • Therapeutic Irrigation
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents