Whole-exome sequencing identified a homozygous FNBP4 mutation in a family with a condition similar to microphthalmia with limb anomalies

Am J Med Genet A. 2013 Jul;161A(7):1543-6. doi: 10.1002/ajmg.a.35983. Epub 2013 May 23.

Abstract

Microphthalmia with limb anomalies (MLA), also known as Waardenburg anophthalmia syndrome or ophthalmoacromelic syndrome, is a rare autosomal recessive disorder. Recently, we and others successfully identified SMOC1 as the causative gene for MLA. However, there are several MLA families without SMOC1 abnormality, suggesting locus heterogeneity in MLA. We aimed to identify a pathogenic mutation in one Lebanese family having an MLA-like condition without SMOC1 mutation by whole-exome sequencing (WES) combined with homozygosity mapping. A c.683C>T (p.Thr228Met) in FNBP4 was found as a primary candidate, drawing the attention that FNBP4 and SMOC1 may potentially modulate BMP signaling.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / genetics*
  • Exons
  • Family
  • Female
  • Homozygote
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Mutation*
  • Osteonectin / genetics
  • Pedigree
  • Sequence Analysis / methods
  • Waardenburg Syndrome / genetics*

Substances

  • Carrier Proteins
  • FNBP4 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Osteonectin
  • SMOC1 protein, human

Supplementary concepts

  • Anophthalmos with limb anomalies