The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jun;115(6):e24-31. doi: 10.1016/j.oooo.2011.10.040. Epub 2012 May 30.

Abstract

Objectives: The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant.

Study design: Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks.

Results: The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P < .05).

Conclusions: Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alveolar Process / physiopathology
  • Alveolar Process / surgery*
  • Analysis of Variance
  • Animals
  • Bone Morphogenetic Protein 2 / pharmacology*
  • Bone Regeneration / drug effects*
  • Coated Materials, Biocompatible / pharmacology*
  • Dental Implantation, Endosseous / methods*
  • Dental Implants*
  • Dogs
  • Male
  • Vascular Endothelial Growth Factor A / pharmacology*

Substances

  • Bone Morphogenetic Protein 2
  • Coated Materials, Biocompatible
  • Dental Implants
  • Vascular Endothelial Growth Factor A