Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3806-9. doi: 10.1016/j.bmcl.2013.04.073. Epub 2013 May 7.

Abstract

In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 μM, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cell Line
  • Diarylheptanoids / chemistry
  • Diarylheptanoids / isolation & purification
  • Diarylheptanoids / pharmacology*
  • Dioscorea / chemistry*
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / biosynthesis
  • Rhizome / chemistry*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Diarylheptanoids
  • Nitric Oxide