Abstract
Sir John Gurdon and Professor Shinya Yamanaka were the recipients of the 2012 Nobel Prize for Physiology or Medicine. This Spotlight article is a commentary on the early nuclear transplant work in Xenopus, which was very important for the Nobel award in 2012, and the influence of this work on the reprogramming field.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation
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Cell Nucleus / genetics*
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Cell Nucleus / metabolism
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Cellular Reprogramming
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Cloning, Organism / history
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Cloning, Organism / methods*
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Embryo, Nonmammalian / cytology
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Embryo, Nonmammalian / embryology
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Embryo, Nonmammalian / metabolism
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Embryonic Development
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Endoderm / cytology
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Endoderm / metabolism
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Epigenesis, Genetic
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History, 20th Century
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History, 21st Century
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Mice
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Nobel Prize
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Nuclear Transfer Techniques / history
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Ovum / cytology*
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Ovum / metabolism
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Physiology / history
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Xenopus / embryology
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Xenopus / genetics