Patient autoantibodies induce platelet destruction signals via raft-associated glycoprotein Ibα and Fc RIIa in immune thrombocytopenia

Haematologica. 2013 Jul;98(7):e70-2. doi: 10.3324/haematol.2013.087874. Epub 2013 May 28.
No abstract available

Keywords: Fc receptor; GPIbα; autoantibodies; immune thrombocytopenia; platelet activation.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Autoantibodies / metabolism
  • Autoantibodies / physiology*
  • Blood Platelets / immunology*
  • Blood Platelets / metabolism
  • Blood Platelets / pathology
  • Female
  • Humans
  • Macrophages / immunology
  • Macrophages / metabolism
  • Macrophages / pathology
  • Membrane Microdomains / immunology*
  • Membrane Microdomains / metabolism
  • Platelet Glycoprotein GPIb-IX Complex / immunology*
  • Platelet Glycoprotein GPIb-IX Complex / metabolism
  • Receptors, IgG / immunology*
  • Receptors, IgG / metabolism
  • Signal Transduction / immunology*
  • Thrombocytopenia / blood
  • Thrombocytopenia / immunology*
  • Thrombocytopenia / pathology*

Substances

  • Autoantibodies
  • Fc gamma receptor IIA
  • Platelet Glycoprotein GPIb-IX Complex
  • Receptors, IgG