Monoclonality of composite large-cell neuroendocrine carcinoma and invasive intestinal-type mucinous adenocarcinoma of the cervix: a case study

Int J Gynecol Pathol. 2013 Jul;32(4):416-20. doi: 10.1097/PGP.0b013e318261c35b.

Abstract

A rare case of mixed carcinoma of the cervix is reported, composed of a large-cell neuroendocrine carcinoma and an invasive intestinal-type mucinous adenocarcinoma. The large-cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium-sized to large-sized cells, and was positive for chromogranin-A and CD56. The invasive intestinal-type mucinous adenocarcinoma showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large-cell neuroendocrine carcinoma may have arisen from the invasive mucinous adenocarcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Mucinous / pathology*
  • Adenocarcinoma, Mucinous / surgery
  • Adult
  • CD56 Antigen / metabolism*
  • Carcinoma, Large Cell / pathology*
  • Carcinoma, Large Cell / surgery
  • Carcinoma, Neuroendocrine / pathology*
  • Carcinoma, Neuroendocrine / surgery
  • Cervix Uteri / pathology
  • Chromogranin A / metabolism*
  • Clone Cells
  • DNA, Neoplasm / genetics
  • Female
  • Humans
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery
  • Receptors, Androgen / genetics

Substances

  • AR protein, human
  • CD56 Antigen
  • Chromogranin A
  • DNA, Neoplasm
  • NCAM1 protein, human
  • Receptors, Androgen