P97/CDC-48: proteostasis control in tumor cell biology

Cancer Lett. 2013 Aug 28;337(1):26-34. doi: 10.1016/j.canlet.2013.05.030. Epub 2013 May 29.

Abstract

P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette - containing AAA+ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology.

Keywords: CDC-48; Cancer; Proteostasis; VCP; p97.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors
  • Adenosine Triphosphatases / physiology*
  • Animals
  • Autophagy
  • Cell Cycle Proteins / antagonists & inhibitors
  • Cell Cycle Proteins / physiology*
  • DNA Damage
  • Endoplasmic Reticulum / metabolism
  • Homeostasis
  • Humans
  • Lysosomes / metabolism
  • NF-kappa B / physiology
  • Neoplasms / etiology*
  • Neoplasms / therapy
  • Valosin Containing Protein

Substances

  • Cell Cycle Proteins
  • NF-kappa B
  • Adenosine Triphosphatases
  • VCP protein, human
  • Valosin Containing Protein