Subtype B was the dominant strain among HIV type 1 infections except for the population of men who have sex with men in Harbin City, China

AIDS Res Hum Retroviruses. 2013 Sep;29(9):1260-4. doi: 10.1089/aid.2013.0135. Epub 2013 Jun 28.

Abstract

We sought to identify the prevalent subtypes and study the genetic variation of HIV-1 circulating in HIV infections in Harbin City, China. Forty-seven samples from the env V3-V4 region were successfully sequenced and analyzed, which involved thirty-one men who have sex with men (MSM), eight heterosexuals, seven former plasma donors (FPD)/blood transfusion recipients (BT), and one injection drug user (IDU). In all, 46.8% of CRF01_AE, 40.4% of subtype B, and 12.8% of CRF07_BC were identified. CRF01_AE (64.5%) was the dominant strain in MSM, and subtype B (81.2%) was the chief strain in other infected subjects except for the MSM population. Among all the genotypes, the B subtype possesses greater diversity of the tetramer on the tip of V3 loop than CRF07_BC and CRF01_AE, in which the peculiar GWGR was commonly found. Because nationwide there is a trend toward the increasing presence of CRF01_AE, a consecutive surveillance campaign was necessary among all HIV vulnerable populations in this locality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Blood Donors
  • China / epidemiology
  • Drug Users
  • Genes, env
  • Genetic Variation
  • Genotype
  • HIV Infections / epidemiology*
  • HIV Infections / virology
  • HIV-1 / classification*
  • HIV-1 / genetics
  • HIV-1 / isolation & purification
  • Homosexuality, Male*
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Analysis, RNA
  • Sexual Behavior

Associated data

  • GENBANK/KC953044
  • GENBANK/KC953045
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