Translationally related nearly identical molecules: 4-methoxyphenyl 4-O-[6-O-acetyl-2-azido-3-O-benzyl-2-deoxy-4-O-(fluoren-9-ylmethoxycarbonyl)-α-D-glucopyranosyl]-2-O-benzoyl-3-O-benzyl-6-O-chloroacetyl-β-D-glucopyranoside

Acta Crystallogr C. 2013 Jun;69(Pt 6):679-82. doi: 10.1107/S010827011301367X. Epub 2013 May 29.

Abstract

The title compound, C59H56ClN3O16, is an important dissacharide precursor to novel therapeutics for the treatment of Alzheimer's disease. It crystallizes with two independent enantiomerically identical molecules in almost exactly the same orientation in the cell, being one half cell-edge apart. Apart from the conformation of a single benzyl group, the molecules are superimposable. They are bound efficiently using complementary C-H···O(carbonyl) hydrogen bonds, principally along the `duplicating' axis. The absolute configurations were determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azides / chemical synthesis*
  • Crystallography, X-Ray
  • Disaccharides / chemical synthesis*
  • Fluorenes / chemical synthesis*
  • Molecular Conformation
  • Molecular Structure
  • Stereoisomerism

Substances

  • Azides
  • Disaccharides
  • Fluorenes