Enantioselective intramolecular aldehyde α-alkylation with simple olefins: direct access to homo-ene products

J Am Chem Soc. 2013 Jun 26;135(25):9358-61. doi: 10.1021/ja4047312. Epub 2013 Jun 12.

Abstract

A highly selective method for the synthesis of asymmetrically substituted carbocycles and heterocycles from unactivated aldehyde-olefin precursors has been achieved via enantioselective SOMO-catalysis. Addition of a catalytically generated enamine radical cation across a pendent olefin serves to establish a general asymmetric strategy toward the production of a wide range of formyl-substituted rings with alkene transposition. Conceptually, this novel mechanism allows direct access to "homo-ene"-type products.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Alkenes / chemistry*
  • Alkylation
  • Amines / chemical synthesis*
  • Amines / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Aldehydes
  • Alkenes
  • Amines