The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis

Clin Infect Dis. 2013 Oct;57(7):1001-4. doi: 10.1093/cid/cit393. Epub 2013 Jun 11.

Abstract

We examined the relationship between serum and bronchoalveolar lavage (BAL) galactomannan index (GMI) values and mortality in allogeneic hematopoietic cell transplant recipients with invasive pulmonary aspergillosis. Using a clinical sign and symptom-initiated approach, we found that the serum but not the BAL GMI level correlated with 42- and 180-day patient mortality.

Keywords: Aspergillus; aspergillosis; galactomannan; mortality; transplant.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bronchoalveolar Lavage Fluid / chemistry
  • Cohort Studies
  • Female
  • Galactose / analogs & derivatives
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / mortality*
  • Humans
  • Invasive Pulmonary Aspergillosis / blood
  • Invasive Pulmonary Aspergillosis / mortality*
  • Kaplan-Meier Estimate
  • Male
  • Mannans / blood*
  • Middle Aged
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult

Substances

  • Mannans
  • galactomannan
  • Galactose