How fast does a signal propagate through proteins?

PLoS One. 2013 Jun 6;8(6):e64746. doi: 10.1371/journal.pone.0064746. Print 2013.

Abstract

As the molecular basis of signal propagation in the cell, proteins are regulated by perturbations, such as mechanical forces or ligand binding. The question arises how fast such a signal propagates through the protein molecular scaffold. As a first step, we have investigated numerically the dynamics of force propagation through a single (Ala)[Formula: see text] protein following a sudden increase in the stretching forces applied to its end termini. The force propagates along the backbone into the center of the chain on the picosecond scale. Both conformational and tension dynamics are found in good agreement with a coarse-grained theory of force propagation through semiflexible polymers. The speed of force propagation of [Formula: see text]50Å ps(-1) derived from these simulations is likely to determine an upper speed limit of mechanical signal transfer in allosteric proteins or molecular machines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Conformation
  • Molecular Dynamics Simulation*
  • Peptides / chemistry*
  • Signal Transduction
  • Stress, Mechanical
  • Thermodynamics

Substances

  • Peptides
  • polyalanine

Grants and funding

The authors thank the Klaus Tschira Foundation (http://www.klaus-tschira-stiftung.de) for funding. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.