My brain told me to do it

Jennifer H Kong; Samantha J Butler; Bennett G Novitch

doi:10.1016/j.devcel.2013.05.019

My brain told me to do it

Dev Cell. 2013 Jun 10;25(5):436-8. doi: 10.1016/j.devcel.2013.05.019.

Authors

Jennifer H Kong¹, Samantha J Butler, Bennett G Novitch

Affiliation

¹ Department of Neurobiology, David Geffen School of Medicine at UCLA, 610 Charles Young Drive East, Los Angeles, CA 90095, USA.

PMID: 23763945
DOI: 10.1016/j.devcel.2013.05.019

Abstract

Voluntary motor control requires circuits in the brain to develop synchronously with spinal motor circuitry. In this issue of Developmental Cell,Reimer et al. (2013) demonstrate that this process is coordinated in zebrafish: dopamine released from descending projections modulates formation of motor neurons by attenuating the response of progenitors to Shh signaling.

Publication types

Comment

MeSH terms

Animals
Brain / embryology*
Brain / metabolism*
Dopamine / metabolism*
Gene Expression Regulation, Developmental*
Motor Neurons / cytology*
Regeneration*

Substances

Dopamine