Cancer Stem Cells Activate STAT3 the EZ Way

Shaun D Fouse; Joseph F Costello

doi:10.1016/j.ccr.2013.05.016

Cancer Stem Cells Activate STAT3 the EZ Way

Cancer Cell. 2013 Jun 10;23(6):711-3. doi: 10.1016/j.ccr.2013.05.016.

Authors

Shaun D Fouse¹, Joseph F Costello

Affiliation

¹ Brain Tumor Research Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Activated STAT3 and increased expression of the histone methyltransferase EZH2 are independently associated with the most malignant subset of gliomas. In this issue of Cancer Cell, Kim and colleagues discover that EZH2 enhances STAT3 activation by trimethylating lysine180 in STAT3 and does so preferentially in glioma stem-like cells.

Publication types

Comment

MeSH terms

Animals
Enhancer of Zeste Homolog 2 Protein
Glioblastoma / metabolism*
Humans
Polycomb Repressive Complex 2 / physiology*
STAT3 Transcription Factor / metabolism*

Substances

STAT3 Transcription Factor
EZH2 protein, human
Enhancer of Zeste Homolog 2 Protein
Polycomb Repressive Complex 2

Grants and funding

R01 CA169316/CA/NCI NIH HHS/United States