Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease

Chem Commun (Camb). 2013 Jul 25;49(58):6507-9. doi: 10.1039/c3cc42325e. Epub 2013 Jun 13.

Abstract

Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of Aβ peptide aggregates in the brain. Using ThT fluorescence assays, AFM imaging, NMR and CD spectroscopy, and MD modeling we show that lysozyme - a hydrolytic enzyme abundant in human secretions - completely inhibits the aggregation of Aβ peptides at equimolar lysozyme : Aβ peptide ratios.

MeSH terms

  • Alzheimer Disease
  • Amyloid beta-Peptides / chemistry*
  • Circular Dichroism
  • Fluorescence
  • Humans
  • Microscopy, Atomic Force
  • Muramidase / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Amyloid beta-Peptides
  • Muramidase