Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes

R Robillard; S L Naismith; N L Rogers; E M Scott; T K C Ip; D F Hermens; I B Hickie

doi:10.1016/j.eurpsy.2013.04.001

Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes

Eur Psychiatry. 2013 Sep;28(7):412-6. doi: 10.1016/j.eurpsy.2013.04.001. Epub 2013 Jun 13.

Authors

R Robillard¹, S L Naismith, N L Rogers, E M Scott, T K C Ip, D F Hermens, I B Hickie

Affiliation

¹ Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, 100, Mallett St, 2050 Camperdown, NSW, Australia.

PMID: 23769680
DOI: 10.1016/j.eurpsy.2013.04.001

Abstract

This study evaluated the potential of circadian measures as early markers of mood disorders subtypes. Patients with bipolar disorders had significantly lower levels and later onset of melatonin secretion than those with unipolar depression. Furthermore, abnormal phase angles between sleep, melatonin and temperature were found in several patients.

Keywords: Actigraphy; Bipolar disorder; Circadian; Core body temperature; Depression; Melatonin.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Bipolar Disorder / metabolism
Bipolar Disorder / physiopathology*
Circadian Rhythm / physiology*
Depressive Disorder / metabolism
Depressive Disorder / physiopathology*
Female
Humans
Male
Melatonin / metabolism*
Salvia / metabolism
Sleep / physiology*
Wakefulness / physiology*

Substances

Melatonin