Abstract
The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new Paenibacillus species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C79H115N19O18. KB425796-A (1) showed antifungal activities against Aspergillus fumigatus and the micafungin-resistant infectious fungi Trichosporon asahii, Rhizopus oryzae, Pseudallescheria boydii and Cryptococcus neoformans.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Aspergillus fumigatus / drug effects
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Chromatography, High Pressure Liquid / methods
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Cryptococcus neoformans / drug effects
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification
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Depsipeptides / pharmacology*
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Drug Resistance, Fungal
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Fermentation
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Freeze Drying
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Microbial Sensitivity Tests
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Paenibacillus / metabolism*
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Pseudallescheria / drug effects
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RNA, Bacterial / genetics
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RNA, Ribosomal, 16S / genetics
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Rhizopus / drug effects
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Sequence Analysis, RNA
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Solvents / chemistry
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Trichosporon / drug effects
Substances
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Antifungal Agents
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Depsipeptides
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KB425796-A
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RNA, Bacterial
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RNA, Ribosomal, 16S
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Solvents