Tumor suppression: p53 alters immune surveillance to restrain liver cancer

Curr Biol. 2013 Jun 17;23(12):R527-30. doi: 10.1016/j.cub.2013.04.076.

Abstract

The p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. A new study reveals that p53 also acts through a novel non-cell-autonomous mechanism, by stimulating the innate immune system to maintain tissue homeostasis and suppress tumorigenesis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic*
  • Cellular Senescence*
  • Hepatic Stellate Cells / metabolism*
  • Humans
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / pathology*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Tumor Suppressor Protein p53